The effect of natural killer cells level in bone marrow on the prognosis of patients with acute myeloid leukemia

Objective: To explore the effects of natural killer (NK) cells in bone marrow on the prognosis of patients with acute myeloid leukemia(AML). Methods: Sixty patients with AML were divided into original treating group(40 cases) and remission group (20 cases), 20 health people were served as control group． The CD16 + /CD56 + of monoclonal antibodies in bone marrow nucleatedcells of three groups were detected by direct immunofluorescence labeling method， the levels of NK cells were determined with flowcytometry． Results: The levels of NK in original treating group were significantly lower than those in remission group(P ＜ 0． 01), the levels of NK in remission group were significantly lower than those in normal group(P ＜ 0． 05). The original cell number in different NK cell levels and the differences of curative effect in AML patients were statistically significant(P ＜ 0． 01 and P ＜ 0． 05). Conclusions:The level of NK cells in bone marrow is a prognostic index of AML and can help to guide treatment．