The expression of Dicer in gastric cancer tissues and its clinical significance

Objective: To explore the expression of Dicer in gastric cancer tissue and its clinical significance． Methods: The expressions of Dicer in 40 gastric cancer specimens and 40 normal gastric specimens were detected by immunohistochemistry，the clinical data were statistically analyzed． Results:The positive rate of the Dicer expression in gastric cancer tissue(47． 5%) was lower than that in adjacent normal tissue(85． 0%)(P 0． 01)． The positive rates of the Dicer expression in high and moderate differentiated gastric cancer tissue and patients with lymph node metastasis and early clinical stage were higher than that in low and undifferentiated gastric cancer tissue and patients with no lymph node metastasis and advanced clinical stage(P 0． 05 to P 0． 01)． The expression differences of Dicer in gender，age and cancer primary site had no statistical significance(P0． 05)． Conclusions:The expression of Dicer in gastric cancer tissue obviously reduces，which is correlated with the differentiation degree lymph node metastasis of clinical stage，gastric cancer．