Sodium citrate for anticoagulation in continuous hemoperfusion

Objective:To evaluate the anticoagulation effect of sodium citrate in continuous hemoperfusion． Methods:Thirty-five patients with severe organophosphorus pesticide poisoning were treated by continuous hemoperfusion using low-molecular-weight heparins or sodium citrate for anticoagulation． The changes of transmembrane pressure during the treatment were compared between the 2 groups;meanwhile，the platelet，APTT，HCO－ 3，iCa2 +，Na+ after treatment and the incidence of bleeding with in 24 hours were also compared． Results:Compared with the sodium citrate group，the transmembrane pressures of the low-molecular-weight heparins group at 2 h and 4 h after treatment were increased significantly(P 0． 01);after treatment，the APTT were extended significantly(P 0． 01)， but the platelet，HCO－ 3，iCa2+and Na+had no obviously changes(P ＞0． 05)． Conclusions:It is feasible and safe to use sodium citrate for anticoagulation in the continuous hemoperfusion．