Clinical analysis of 40 children with primary nephrotic syndrome

Objective:To investigate the clinical characteristics of children with primary nephrotic syndrome． Methods:The clinical data of 40 children with primary nephrotic syndrome(including 31 cases of simple nephrotic syndrome and 9 cases of nephritis nephropathy) were retrospectively analyzed． Results:Edema was the major clinical manifestation of children，and the primary reason for seeing doctor． All children were treated with rest，limiting sodium intaking and adrenal cortical hormone and cytotoxic drugs． The complete remission rates of simple nephrotic syndrome and nephritis nephropathy were 70． 1% and 33． 3%，respectively． Respiratory tract infection in 9 cases，hyponatremia in 4 cases，hypothyroidism in 2 cases，acute renal insufficiency in 2 cases and cerebral embolism in 1 case were found． Conclusions:The complete remission rate of simple nephrotic syndrome treated with prednisone is higher than that in nephritis nephropathy treated with prednisone． Immune inhibitor in the treatment of steroid-resistant children with primary nephrotic syndrome has certain effect． The complications of patients and compliance education of patients and their families should be strengthened during treatment．