The correlation of SGSM3 rs56228771 polymorphisms and susceptibility of colorectal cancer in Han people

Objective: To explore the correlation of SGSM3 rs56228771 polymorphisms and susceptibility of colorectal cancer in Han people.Methods: The distribution frequencies of SGSM3 rs56228771 in 339 Han patients with colorectal cancer(colorectal neoplasm group) and 319 healthy people were detected using non-denaturing PAGE.The odds ratio(OR) and 95% confidence intervals(CI) of age,sex,smoking and drinking status after adjustment were calculated using unconditional logistic regression analysis.Results: The frequencies of SGSM3 I/I,I/D and D/D genotypes in colorectal cancer group and control group were 2.36%,24.78% and 72.86%,and 4.08%,33.86% and 62.07%,respectively,the differences of whose were statistically significant(P<0.05).The risk of colorectal cancer in cases with SGSM3 I/I genotype was lower than that in cases with D/D genotype(OR=0.62,95%CI 0.20 to 1.21,P<0.05).The risk of colorectal cancer in cases with SGSM3 I gene was lower than that in cases with D gene(OR=0.49,95%CI 0.49 to 0.87,P<0.01).Conclusions: The SGSM3 rs56228771 polymorphism is directly related to the susceptibility of colorectal cancer in Han people.