Clinical observation of docetaxel plus cisplatin versus gemcitabine plus cisplatin in treatment of advanced non-small cell lung caner

Objective: To compare the efficacy and side effects of docetaxel/cisplatin regiment(DP) and gemcitabine/cisplatin regiment(GP) in treatment of advanced non-small cell lung cancer(NSCLC).Methods: A total of 80 patients with advanced NSCLC were randomized into 2 groups.The patients in docetaxel group were received docetaxel at 37.5 mg/m² on day 1 and day 8,cisplatin at 75 mg/m² on day 2 to day 4.In gemcitabine group,the patients were received gemcitabine at 1 000 mg/m² on day 1 and day 8,and the same method of cisplatin as in docetaxel group.The treatment schedule was recycled every 3 weeks.The toxicity and life quality were evaluated after every cycle.The efficacy and survival rate were evaluated at the end of two cycles.Results: The response rates in docetaxel group and gemcitabine group were 45.00% and 42.50% respectively.The main side effects were myelosuppression,nausea and vomiting.Conclusions: Docetaxel/cisplatin and gemcitabine/cisplatin regiments had the high efficacys in treatment of advanced NSCLC patients.