Comparison of MxEP and EP regimen in treatment for advanced non-small cell lung cancer

Objective: To observe and compare the effect and major adverse reaction of the two chemotherapy regimens(MxEP and EP) in treatment of advanced non-small cell lung cancer (NSCLC).Methods: Thirty cases of advanced NSCLC (stage Ⅲ-Ⅳ) patients were treated with MxEP regimen(MxT 10 mg,d₂;VP16 75 mg/m²,d_1-5;DDP 30 mg/m²,d_1-3),and the other 27 cases were treated with EP regimen (VP 16 75 mg/m²,d_1-5;DDP 30 mg/m²,d_1-3).Results: In the MxEP group,the overall response rate was 56.7%(CP+PR=17),the medium response time was 6 months and the medium survival time was 13 months.In the EP group,the overall response rate was 33.3%(CP+PR=11),the medium response time and medium survival time were 3 and 8 months.The major side effects were anorexia,nausea,vomiting,leucopenia and thrombocytopenia,which were tolerable for most cases.Conclusions: The MxEP regimen is a good choice for treatment of NSCLC.