Inhibitory effect of minocycline on the growth, metastasis and angiogenesis of lung carcinoma in mice

Objective: To investigate the effects of minocycline(MC) on the growth and metastasis of lung carcinoma and tumor angiogenesis.Methods: T739 mice with lung carcinoma were used in this study.The rats were injected MC,cyclophosphamide(CTX) or normal saline(NS).The tumor growth delay and numbers of the metastatic foci on lungs and the expression of vascular endothelial growth factor(VEGF) of lung carcinoma were observed.Results: MC remarkably reduced the numbers of the metastatic foci and the expression of VEGF of lung carcinoma,and increased the tumor growth delay(P<0.01).Conclusions: MC can obviously inhibit the growth and metastasis of lung carcinoma in mice,and its mechanism is related to the expression of VEGF and angiogenesis.