Expression of nuclear factor κB and vascular endothelial growth factor in retinoblastoma and its clinical significance

Objective:To investigate the expression of nuclear factor κB (NF-κb) and vascular endothelial growth factor (VEGF) in retinoblastoma (RB),and its relationship with the differentiation and optic nerve infiltration.Methods:The expression of NF-κB and VEGF was examined in 33 cases of RB tissue using immunohistochemistry.The relationship between the differentiation and invasion among NF-κB,VEGF and RB was analyzed statistically.Results:The expression of RB in NF-κB and VEGF was obviously higher than that in normal retina (P<0.01),and the expression was related to the differentiation degree of RB (P=0.027).The expression of VEGF was significantly different between invasive and non-invasive optic nerves of RB (P=0.033).Conclusions:NF-κB and VEGF are both involved in the formation of RB,and VEGF may be associated with the invasion of RB.