The influence of arsenic trioxide on adhesion and migration in melanoma B16 cells

Objective: To investigate the influence of arsenic trioxide (As₂O₃) on migration and adhesion capability in melanoma B16 cells,and evaluate the effect of As₂O₃ on anti-invasion and anti-metastasis ability.Methods: The invasion and migration capacities of melanoma B16 cells were evaluated using Transwell Permeable Supports.The adhesion capacity of melanoma B16 cells was evaluated by MTT assay.The expression of adhesion molecule CD44 was detected by FCM.Results: As₂O₃ significantly inhibited the adhesion and migration capacities of melanoma B16 cells (P<0.05 to P<0.01) and down-regulated the expression level of CD44 (P<0.01).Conclusions: As₂O₃ has the effect of antagonizing invasion and metastasis in melanoma B16 cells,the mechanism maybe related to decrease the expression of adhesion molecule CD44.