Expression and clinicopathologic significance of FEZ1/LZTS1 mRNA in bladder transitional cell carcinomas

Objective: To investigate the expression of FEZ1/LZTS1 mRNA and evaluate its effects on the tumorigenesis and progression in bladder transitional cell carcinomas (BTCCs).Methods: The expression of FEZ1/LZTS1 mRNA in 40 BTCCs and 10 normal bladder mucosas was detected by RT-PCR.Results: The negative expression of FEZ1/LZTS1 mRNA in BTCC (57.50%) was significantly higher than that in normal bladder mucosa (P<0.01).Statistical analysis showed a significant association between the Absence of FEZ1/LZTS1 mRNA and the histological grade of BTCC.The negative expression of FEZ1/LZTS1 mRNA was 28.57%,61.54% and 84.62% in gradeⅠ,gradeⅡ and grade Ⅲ BTCC,respectively (P<0.05).The negative expression was 28.57% and 89.47% in Ta-T1 BTCC and T2-T4 BTCC,respectively (P<0.01).Conclusions: The Absence of FEZ1/LZTS1 mRNA expression in BTCC is up-regulated and associated with the histological grade and the clinical stages of BTCC.The Absence of FEZ1/LZTS1 expression might act as a reference indicator in evaluating the differentiation of the tumor and predicting the prognosis.