MA Xiao-feng, SHEN Xiao-hui, YU Chen-jie, ZHANG Yi-fen, QIAN Xiao-yun. Expression of E-cadherin and its prognostic value in human laryngeal carcinoma of human larynx[J]. Journal of Bengbu Medical University, 2014, 39(7): 858-860.
    Citation: MA Xiao-feng, SHEN Xiao-hui, YU Chen-jie, ZHANG Yi-fen, QIAN Xiao-yun. Expression of E-cadherin and its prognostic value in human laryngeal carcinoma of human larynx[J]. Journal of Bengbu Medical University, 2014, 39(7): 858-860.

    Expression of E-cadherin and its prognostic value in human laryngeal carcinoma of human larynx

    • Objective: To investigate the expression of E-cadherin(ECD) and its clinical value in predicting the prognosis of laryngeal carcinoma.Methods: The expression of ECD was determined by immunohistochemistry with EnVision two-step method on tissue microarray slides in 79 cases of laryngeal carcinoma tissues;the relationship between the pathological features and the prognosis was analyzed.Results: Negative expression of ECD was detected in 11 cases of the tissue(13.3%);The ECD expression had no statistical differences between the clinical and the pathological features of the patients with the laryngeal carcinoma(P>0.05).The positive rates of ECD were 76.74% and 94.44% in the dead patients and the survival ones respectively;the difference was statistically significant(P<0.05).Conclusions: The ECD expression may be of great value in predicting the prognosis of patients with the laryngeal carcinoma.
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