Effect of the sufentanil combined with dexmedetomidine on postoperative analgesia in cervical cancer patients with radical hysterectomy

Objective: To observe the effects of sufentanil combined with dexmedetomidine on postoperative analgesia in cervical cancer patients with radical hysterectomy.Methods: Fifty-six ASAⅠor Ⅱcervical cancer patients scheduled by radical hysterectomy were randomly divided into the observation group and control group(28 cases each group).At postoperative analgesia,the control group were treated with sufentanil for 1.0 μg·kg^-1·d^-1,the observation group were treated with sufentanil for 1.0 μg·kg^-1·d^-1 combined with dexmedetomidine for 1.0 μg·kg^-1·d^-1,the postoperative analgesia continuous perfusion amount for 2 ml/h,single bolus for 2 ml,lockout time for 15 min and total volume for 100 ml were implemented in two groups.The degree of pain and sedation grade in two groups were evaluated using visual analog scale(VAS) after operation(T₁) and at 2(T₂),8(T₃),24(T₄) and 48 hours(T₅) after operation.The incidences of bladder discomfort,nausea and vomiting,and satisfaction of patients in two groups were recorded after operation.Results: The postoperative VAS scores in two groups in all time points were less than 4.The pain scores of the observation group at T₂ to T₅ were significantly lower than that of the control group(P<0.01).The Ramesay grades of the observation group at T₂ to T₅ were significantly lower than that of the control group(P<0.01).The incidences of bladder discomfort,nausea and vomiting in observation group were lower than those in control group(P<0.05),the satisfaction of patient in observation group were higher than that in control group(P<0.05).Conclusions: The postoperative analgesia effects of sufentanil combined with dexmedetomidine on radical hysterectomy are better than that of sufentanil,which is lower adverse reaction and more comfortable.