Effect of high dose of intravenous immunoglobulin on Guillain-Barre syndrome

Objective: To observe the therapeutic effect of high dose of intravenous immunoglobulin (IVIG) in treatment of Guillain-Barre syndrome (GBS).Methods: Eleven patients with GBS were treated with IVIG in a dose of 0.4 g·kg^-1·d^-1for 5 consecutive days,and the other 16 patients were treated with steroid.The therapeutic effect was compared.Results: The IVIG-treated group was superior to the steroid-treated group in cynical grading scale and time of response(P<0.05 and P<0.001),but there was no significant difference in the total effective rate.Conclusions: Treatment of Guilian-Barre syndrome with high dose of IVIG is superior to that with steroid in clinical grading scale and time of response.