High dose of cisplatin combined with 5-fluorouracil/leucovorin plus medroxypro-gesterone acetate in treatment of advanced castric and colorectal adenocarcinoma

Objective: To evaluate the therapeutic effect and side effect of high dose of cisplatin(HD DDP) combined with fluorouracil(5-Fu)/leucovorin(CF) plus medroxyprogesterone acetate(MPA) on advanced gastric and colorectal adenocarcinoma.Methods: Twenty three cases of advanced gastric adenocarcinoma cases and 14 cases of advanced colorectal adenocarcinoma were treated with HD-DDP+5-Fu/CF+MPA regimen.Results: Effectiveness was noted in 10 cases in gastric adenocarcinoma group and 5 cases in the other;the overall responses rate(CR+PR) was 40.5% and 35.7% respectively.The main side-effects were nausea and vomiting,which reached degree Ⅱ or higher(24.3%).BUN elevation was observed only in two cases.Conclusions: HD-DDP+5-Fu/CF+MPA regimen proves to be effective and its side-effects are slight and endurable.