Clinical significance of fibrinogen receptor expression on circulating activated platelets in patients with cerebral infarction

Objective: To explore the clinical significance of the fibrinogen receptor(FIB-R) expression on the circulating activated platelets(CAP) in patients with cerebral infarction.Methods: The levels of FIB-R expression on CAP were detected by flow cytometry(FCM) in the blood of 10 healthy controls,20 patients with thrombotic tendency and 20 patients with acute cerebral infarction before and after treatment.Results: The FIB-R expression levels on CAP were markedly higher(P<0.01) in patients with thrombotic tendency and the ones with acute cerebral infarction than that in the healthy controls.The expression levels of FIB-R on CAP before and after treatment were significantly different(P<0.01).Conclusions: The level of platelet activation can be reflected accurately by detection of FIB-R expression on CAP,which is of great value for the prediction,treatment,supervision of curative effect and estimation of prognosis in patients with cerebral infarction.