Relationship between rheumatoid arthritis and pyridinoline cross-linked carboxy-terminal telopeptide of type Ⅰ collagen

Objective: To observe the change of pyridinoline cross-linked carboxy-terminal telopeptide type Ⅰ collagen(ICTP) in the serum of patients with rheumatoid arthritis(RA).Methods: The serum level of ICTP was determined in 45 patients with RA,31 patients with osteoarthritis(OA) and 32 healthy individuals by enzyme linked immunosorbent assay,and the erythrocyte sedimentation rate(ESR) and C reactive protein(CRP) of the 45 patients with RA were also detected.Results: The serum level of ICTP in the RA group was remarkably higher than that in the healthy and OA groups(P<0.01).The ICTP was directly correlated with ESR in the patients with RA and CRP(P<0.01),but had no relation with the radiogram staging(P>0.05).Conclusions: The serum level of ICTP in the patients with RA can reflect the progression of the disease.