Preparation of 2-pyridylboronic acid

Objective:To investigate the means of preparing 2-pyridylboronic acid.Methods:The product was synthesized with 2-bromopyridine,tris-trimethylsilylborate and iPrMgCl as Grignard reagents under N₂,and identified by 1H-NMR.Results:2-pyridylboronic acid was synthesized with the yield of 67.7% on conditions of n (tris-trimethylsilylborate):n (2-bromopyridine)=2:1;the reaction temperature was 0℃,the reaction time 3 hours and the hydrolysis temperature 0℃.Conclusions:2-pyridylboronic acid can be synthesized by Grignard reaction on moderate conditions with high yield,which may contribute to the study of pyridine drugs.