Continuous venous infusion of low-dose of 5-fluorouracil and cisplatin for treatment of advanced gastric cancer

Objective: To assess the efficacy and toxicity of a combination therapy of continuous venous infusion(civ) of low-dose of 5-fluorouracil(5-Fu)and cisplatin in treatment of advanced gastric cancer.Methods: The regimen consisted of 5-Fu 250 mg·m^-2·d^-1 civ,and PDD 6 mg·m^-2·d^-1,5 d/w,which were used for 3 weeks.The effect and the toxicity were evaluated after 2 cycles of treatment.Results: Gross efficiency rate was 52.8% in 1 the case of CR and 18 cases of PR.The Major toxic effect was gastrointestinal tract reaction.Repression of marrow was light.Conclusions: The chemotherapy regimen mentioned above is effective and has little toxic effect.It is suitable for treatment of advanced gastric cancer.