Effect of intravesical instillation of hydroxycamptothecin associated with pirarubicin for preventing postoperative recurrence of superficial bladder cancer

Objective: To observe the effect and safety of intravesical instillation of hydroxycamptothecin(HCPT) associated with pirarubicin(THP) for preventing postoperative recurrence of the superficial bladder cancer.Methods: The intravesical instillation of HCPT associated with THP was performed in 32 patients with bladder cancer after operation and till two years after operation.The local and overall reaction was recorded for each instillation.The cystoscopy was performed once every three months.Results: All the patients were followed up for 9 up to 50 months with 20 months on everage.Recurrence occurred in two patients(6.3%).The aforementioned therapy was tolerated by all patients.Conclusions: The intravesical instillation of HCPT associated with THP is an effective and safe treatment for superficial bladder cancer with good tolerance,less toxic and adverse effects and satisfactory results.