Comparison of the clinical and biochemical features of non-obese and obese women with polycystic ovary syndrome

Objective: To investigate the clinical and biochemical features of non-obese polycystic ovary syndrome(PCOS) patients.Methods: According to the body mass index(BMI),the 81 patients with PCOS were divided into the non-obese group(BMI<25 kg/m²) and obese group(BMI≥25 kg/m²),the clinical and biochemical features between two groups were compared.Results: The normal menstruation and amenorrhea rates in non-obese group and obese group were 24.49% & 5.9% and 8.5% & 26.5%,respectively,the differences of which were statistical significance(P<0.05).The levels of the follicle stimulating hormone(FSH),luteinizing hormone(LH),ratio of LH to FSH and high density lipoprotein cholesterol in non-obese group were higher than those in obese group(P<0.05 to P<0.01),the levels of the fasting plasma glucose,fasting insulin,total cholesterol,triglyceride and low density lipoprotein in non-obese group were significantly lower than those in obese group(P<0.05 to P<0.01).Conclusions: The non-obese PCOS patients are characterized by the dysfunction of hypothalamus-pituitary gland-ovary axis,the obese PCOS patients are characterized by the dysfunction of metabolism disorder of blood lipid and insulin resistance.The clinical diagnosis and treatment should be individualized.