Effect of early enteral nutrition on the repair of intestinal proliferation after burn

Objective: To explore the effects of early enteral nutrition on the repair of intestinal proliferation after burn in rat,and its mechanism.Methods: Eighty-eight Wistar rats with 30% of body surface area Ⅲ degree burn were randomly divided into the normal control group(C group),early enteral nutrition(EEN group) and delayed enteral nutrition(DEN group).The EEN group and DEN group were treated with enteral nutrition at 6 and 24 hours after burn,respectively.The incorporation rates and proliferation indexes of ³H-thymidine nucleoside ³H-TdR,³H-Uridine and ³H-Leucine,and the levels of DNA,RNA and protein in intestinal mucosal were detected before burn and at 0.5,1,3,7 and 10 days after burn.Results: The incorporation rates of ³H-TdR and ³H-Uridine in ileum mucosal of rats at each points after burn were significantly lower than those before burn.The incorporation rates of ³H-TdR,³H-Uridine and ³H-Leucine at 1 to 10 days after burn in EEN group were higher than those in DEN group(P< 0.05 to P< 0.01).The proliferation indexes in intestinal mucosal of rats after burn were lower than those before burn,the incorporation rates at 1 to 10 days after burn in EEN group were higher than that in DEN group(P< 0.05 to P< 0.01).The levels of DNA,RNA and protein of rat ileum mucosal all group decreased remarkably after burn.The levels of DNA,RNA and protein in EEN group were obviously higher than those in DEN group(P< 0.05 to P< 0.01).Conclusions: The early enteral nutrition can effectively reduce the inhibition of intestinal mucosal proliferation,and promote the repair of intestinal mucosa after burn.