Effects of simvastatin on pulse wave velocity and ankle-brachial index in geriatric hypertensive patients with hyperlipemia

Objective: To observe the effect of simvastatin on pulse wave velocity(PWV) and ankle-brachialindex(ABI) in geriatric hypertensive patients with hyperlipemia.Methods: Eighty five patients with hypertension-hyperlipemia were randomly divided into control group(n=40) and simvastatin group(n=45),which were treated for 3 months.Systolic blood pressure(SBP),diastolic blood pressure(DBP),pulse pressure(PP),blood fat,PWV and ABI were measured before and after treatment.Results: Serum total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) and triglyceride(TG) in patients with simvastatin group were more decrease,and high-density lipoprotein cholesterol(HDL-C) was more increase.The levels of SBP,DBP and PP were markedly depressed in The both two groups,but compared with control group,the degrees of decrease of SBP,PP were more.In addition,the PWV were more visibly decreased and ABI increased after treatment than before treatment in two groups.However,compared with control group,the degree of increase in ABI with simvastatin group was more visibly.Conclusions: Simvastatin may improve the vascular function through decreaseing PWV,reducing PP and increasing ABI in geriatric hypertensive patients with hyperlipemia.