Significance of serum level of interleukin-18 in laryngeal cancer

Objective: To investigate the serum level of interleukin(IL)-18 in laryngeal cancer.Methods: The IL-18 concentration in sera was measured in 22 patients with laryngeal cancer,and 10 health control subjects by enzyme-linked immunosorbent assay(ELISA).Results: The concentration of IL-18 in patients with laryngeal cancer(68.44±39.42)pg/ml was significantly higher than that of health control subjects(28.47±2.29)pg/ml(P<0.001).Conclusions: The IL-18 is higher in patients with laryngeal cancer.The concentration of IL-18 may be an important biochemistry predictive sign in assistant diagnoses and monitoring the changes in patients with laryngeal cancer.