Effects of triphosadenine on preventing cardiovascular responses during extubation awakening period after general anesthesia

Objective: To observe the effects of triphosadenine (ATP) on preventing cardiovascular responses to endotracheal extubation when a patient came to his consciousness from general anesthesia.Methods: Forty patients (ASA Ⅰ toⅡ) undergone general anesthesia were randomly allocated to observation and control group with 20 cases in each.The patients in observation group were given intravenous drip with ATP at a dose of 0.3 mg/kg 5 min prior to extubation,whereas the patients in control group were received no medication.Systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR) and mean arterial pressure (MAP) were recorded at 5 min before extubation,during extubation,at 1,3 and 6 min after extubation,and RPP was determined.Results: The indexes at 5 min before extubation in the two groups showed no significant difference (P>0.05).There were no significant differences in SBP,DBP,MAP and HR between 5 min before extubation and during extubation,at 1,3 and 6 min after extubation in observation group (P>0.05),and RPP was increased only in extubation time (P<0.05).Compared with 5 min before extubation,all indexes were significantly increased during extubation,at 1 min after extubation in control group (P<0.05-P<0.01),and the value of SBP,MAP,HR and RPP were significantly increased at 3 min after extubation,too (P<0.05-P<0.01).All indexes at 6 min after extubation were similar to the level 5 min before extubation in control group (P>0.05).All indexes in observation group were significantly decreased during extubation,at 1 min and 3 min after extubation compared with control group (P<0.05-P<0.01).Conclusions: ATP can prevent patients from cardiovascular response effectively when patients are in condition of extubation in palinesthesia.