Effect of cyclophosphamide combined with large doses of methylprednisolone on the serum level of matrix metalloproteinase 9 of patients with paraquat poisoning

Objective: To explore the effects of cyclophosphamide combined with large doses of methylprednisolone on the serum level of matrix metalloproteinase 9(MMP-9) of patients with paraquat poisoning.Methods: Fifty patients with acute paraquat poisoning were treated with cyclophosphamide combined with large doses of methylprednisolone on the basis of additional treatment.The levels of serum MMP-9 in all patients were detected before and after treatment.Results: Compared with before treatment,the serum levels of MMP-9 in patients decreased significantly after treatment(P< 0.01).Conclusions: The treatment of cyclophosphamide combined with large doses of methylprednisolone can effectively reduce the serum levels of MMP-9 in patients with paraquat poisoning,which maybe one of the mechanisms of reducing lung injury.