Effects of different doses of dezocine on tracheal extubation reaction and postoperative agitation in patients undergoing gastric cancer surgery with general anesthesia

Objective: To explore the influence of different doses of dezocine on anesthesia tracheal extubation reaction and postoperative agitation of patients receiving gastric cancer surgery.Methods: Eighty ASA ⅠorⅡ patients undergoing elective gastric cancer surgery were randomly divided into four groups,with 20 cases in each one.The four groups were respectively given 0.05 mg/kg of intravenous dezocine(group D1),0.1 mg/kg of intravenous dezocine(group D2),0.2 mg/kg of intravenous dezocine(group D3) and 0.9% sodium chloride injection 2 ml(group N) 20 minutes before the end of the surgery.The MAP,HR,RR and SpO₂ were observed and recorded before the induction(T₀),the time of sputum suction before extubation(T₁),immediately after extubation(T₂),and 5 min(T₃) and 10 min(T₄) after extubation.The postoperative recovery time of spontaneous breathing and awakening,the extubation time,the tube drawing quality score and the postoperative agitation score(RS) were also recorded.The pain degree was assessed with verbal rating scale(VRS) 5 minutes after revival from general anesthesia.Results: Compared with T₀,the MAP rose obviously at T₁-T₃ in group D1,at T₁-T₂ in group D2,at T₁ in group D3 and at T₁-T₄ in group N(P<0.05 to P<0.01);the HR rose obviously at T₁-T₄ in group D1 and group N,at T₁ and T₃ in group D2 and group D3(P<0.01);compared with group N,the MAP decreased obviously at T₁-T₂ in group D2 and at T₁-T₄ in group D3(P<0.05 to P<0.01);HR slowed significantly at T₁ and T₃ in group D2,and at T₁-T₄ in group D3(P<0.05 to P<0.01).The recovery time of spontaneous breathing,awakening and the extubation time was obviously lengthened in group D3(P<0.01);there were no statistically significant differences among group D1,D2 and group N(P<0.05).The tube drawing quality score of group D1,D2 and D3 was superior to that of group N(P<0.01),and group D2 was better than group D1(P<0.01);The postoperative agitation score of group D2 was superior to that of group D1 and group N(P<0.01).The VRS score of group D1,D2 and D3 was superior to that of group N 5 min after extubation(P<0.01),and group D2 and D3 had higher score than group D1(P<0.05).Conclusions: Different doses of dezocine can reduce the tracheal extubation reaction of patients with general anesthesia.And 0.1 mg/kg dezocine may effectively inhibit the anesthesia tracheal extubation reaction and postoperative agitation,but has no significant influence on the recovery time of spontaneous breathing or awakening.