The expressions of CD44v6 and PTEN in renal cell carcinoma and its clinical significance

Objective: To investigate the expressions of CD44v6 and PTEN in renal cell carcinomal (RCC) and its clinical significance.Methods: The expressions of CD44v6 and PTEN were examined by immunohistochemistry S-P method in 20 cases of Para carcinoma,10 cases of normal renal tissues and 60 cases of RCC;And the pathobiologic behavior was analyzed.Results: The positive rates of CD44v6 and PTEN in RCC were 51.7% and 66.7%,respectively.The histological grading,clinical staging and metastases potential of RCC were correlated with high expression of CD44v6 and low expression of PTEN (P<0.01).The expression of CD44v6 was negatively correlated with the expression of PTEN (P<0.05-P<0.01).Conclusions: The result suggests that high expression of CD44v6 and low expression of PTEN might be a useful indicator for evaluation of the differentiation of tumors and prediction of lymph nodes metastasis.