Study on the efficacy and safety of doxifluridine in treatment of advanced gastric cancer and colorectal cancer

Objective: To evaluate the efficacy and safety of doxifluridine in treatment of old and weak patients with advanced gastric and colorectal cancer.Methods: Twenty cases of advanced gastric and colorectal cancer were given doxifluridine 200 mg four times daily for 14 days,followed by a week rest.The regime was repeated for 2-3 cycles.Results: Among the patients,CR was found in 0 cases,PR in 6 cases,SD in 9 cases and PD in 5 cases.the overall response rate was 30%.There were few adverse events.WHO grade Ⅰ/Ⅱ leukopenia occurred in 5 cases(25%),grade I thrombocytopenia occurred in 2 cases(10%),gradeⅠ/Ⅱ nausea and vomiting in 3 cases(15%),and the damage to the liver and kidney and heart function was not obvious.Conclusions: Doxifluridine has certain effect on patients with advanced gastric and colorectal cancer,with slight toxin or side effects.