Influence of remifentanil,fentanyl combined with propofol in induction of anaesthesia on hemodynamic changes during intubation

Objective: To compare the influences of remifentanil,fentanil combined with propofoil on the hemodynamic changes during intubation.Methods: Forty operation patients under general anesthesia were randomly divided into two groups:group R(group remifentanil) and group F(group fentanil).Anesthesia was induced with intravenous propofol 2 mg/kg and rocuronium 0.6 mg/kg.Remifentani 2 μg/kg was used in group R and fentanyl 3 μg/kg in Group F.The systolic blood pressure(SBP),diastolic blood pressure(DBP)and heart rate(HR)were measured before anesthesia induction(T₁),1 minute after induction(T₂)and 2 minutes after endotracheal intubation(T₃).Results: Compared with the baseline,blood pressure and HR decreased significantly after induction in the two groups(P<0.01);after endotracheal intubation,the SBP,DBP and HR in group R returned to the baseline(P>0.05).SBP and DBP in group F increased significantly after endotracheal intubation(P<0.05),but HR showed no difference(P>0.05).SBP,DBP and HR in the two groups differed significantly(P<0.01).Conclusions: Remifentanil and fentanyl can inhibit cardiovascular response during intubation,and remifentani is more effective than fentanyl.