Expression of TRAIL receptors in human endometrial carcinoma cell line

Objective: To investigate the expression of death receptors(DR4,DR5) and decoy receptors(DcR1,DcR2) of TNF-related apoptosis inducing ligand(TRAIL) in normal endometrium tissues,carcinoma endometrium tissues and the adjacent tissues.Methods: Reverse transcriptase polymerase chain reaction(RT-PCR) was used to detect mRNA positive expressions of the receptors of TRAIL in 20 cases of normal endometrium tissues,20 cases of carcinoma endometrium tissues and the adjacent tissues.Results: DR4 and DR5 were expressed in normal endometrium tissues,carcinoma endometrium tissues and the adjacent tissues.DcR1 expressed differently in the tissues of endometrium,but with no statistical significance(P>0.05);the expression of DcR2 was much lower in the carcinoma endometrium tissues than in normal or tumor adjacent tissues(P<0.005);the expression of DcR2 was similar in normal and tumor adjacent tissues(P>0.05).Conclusions: The low expression of DcR2 in the carcinoma of endometrium may be concerned with its pathogenesis,which might play a role in preventing endometrium from carcinomatous change.