Influence of soybean isoflavone on the fat level and anti-lipid peroxides in rats

Objective: To observe the influence of soybean isoflavone(SI) on the fat level and lipid peroxides in rats.Methods: Fifty wistar rats were randomly divided into five groups and fed on foundation feed high fat feed,and high fat feed mixed with 30 mg/kg,90 mg/kg and 270 mg/kg soybean isoflavone respectively.The experiment lasted for 6 weeks.Results: SI could obviously inhibit the rise of low density lipoprotein(LDL) induced by high fat feed in the plasma(P<0.01).SI had preventive effect on the rise of lipid peroxide induced by feed and it improved the activity of GSH px,SOD and CAT(P<0.05 to P<0.01).Conclusions: SI can decrease the hypertriglyceride,improve the abnormal oxidization caused by high fat feed,and alleviate the lesion due to peroxidation.