Objective To explore the correlation between the lipid metabolism, vitamin D deficiency and occurrence of postmenopausal osteoporosis (PMOP), and analyze its predictive value for the occurrence of PMOP.
Methods A total of 160 postmenopausal women were selected for the study. Dual-energy X-ray was used to evaluate the bone mineral density (BMD), and they were divided into the PMOP group and non-PMOP group according to the occurrence of PMOP. The differences of the bone metabolism indicators β-collagen specific sequence (β-CTx), osteocalcin (N-MID) and total type 1 collagen amino-terminal elongated peptide (TP1NP), lipid metabolism indicators total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and 25-hydroxyvitamins levels were compared between two groups. Multivariate logistic regression was used to analyze the related factors influencing the occurrence of PMOP, and the ROC curve was plotted to analyze the diagnostic value of lipid metabolism indicators and 25(OH)D levels for the occurrence of PMOP.
Results Among 160 postmenopausal women, 76 cases developed PMOP and 84 cases did not. The incidence of osteoporosis was 47.5%. The age, duration of menopause, proportion of those with ≥2 births, levels of β-CTx, N-MID and TP1NP in the PMOP group were all higher than those in the non-PMOP group, while the proportion of those with exercise habits, BMD value of femoral neck and BMD value of hip were all lower than those in the non-PMOP group, and the differences were statistically significant (P ＜ 0.05 to P ＜ 0.01). The expression levels of TC, TG and LDL-C in the PMOP group were all higher than those in non-PMOP grou, while the levels of HDL-C and 25(OH)D were all lower than those in the non-PMOP group, and the differences were statistically significant (P ＜ 0.05 to P ＜ 0.01). The results of multivariate logistic regression analysis showed that the age, duration of menopause, frequency of childbirth, exercise habits, BMD, bone metabolism indicators (β-CTx, N-MID, TP1NP), lipid metabolism indicators (TC, TG, LDL-C, HDL-C) and 25(OH)D levels might all be related factors affecting the occurrence of PMOP (P ＜ 0.01). The results of ROC analysis showed that the AUCs of TC, TG, LDL-C, HDL-C and 25(OH)D in diagnosing the occurrence of PMOP were 0.839, 0.834, 0.809, 0.813 and 0.877, respectively. The combined diagnosis AUC was 0.976, and the sensitivity and specificity were 94.74% and 73.81%, respectively.
Conclusions Women with PMOP have abnormal lipid metabolism and 25(OH)D deficiency. The combined detection of lipid metabolism indicators and 25(OH)D level has certain reference value for the early diagnosis of PMOP.
DownLoad: