The relationship between the levels of homocysteine and C-reactive protein and macroangiopathy in type 2 diabetes mellitus

Objective: To investigate the relationship between the levels of homocysteine(Hcy) and C-reactive protein(CRP) and macroangiopathy in type 2 diabetes mellitus.Methods: The levels of plasma Hcy and CRP in control group(30 cases),simple diabetes mellitus group(32 cases) and diabetic macroangiopathy group(31 cases) were detected using immunoturbidimetry.The relationship between the levels of Hcy and CRP and diabetic macroangiopathy was analyzed.Results: The levels of plasma Hcy and CRP in simple diabetes mellitus and diabetic macroangiopathy group were significantly higher than those in control group(P<0.01),the levels of plasma Hcy and CRP in simple diabetes mellitus group were significantly lower than those in and diabetic macroangiopathy group(P<0.01).Logistic regression analysis showed that the levels of systolic blood pressure,diastolic blood pressure,HbA1c,triglyceride,total cholesterol,high density lipoprotein,Hcy and CRP were correlated to artherosclerosis.Conclusions: The levels of plasma Hcy and CRP in type 2 diabetic patients with macroangiopathy increased significantly.The treatment with losing body mass,controlling blood glucose,correcting lipid metabolism disorder,increasing insulin sensitivity reducing blood pressure can prevent and delay the occurrence of artherosclerosis.