Effect of preoperative neoadjuvant chemotherapy on the patients with stageⅠb2 to Ⅱb cervical adenocarcinoma

Objective: To explore the curative effects of neoadjuvant chemotherapy on stageⅠb2 to Ⅱb cervical adenocarcinoma.Methods: Forty-four patients with stageⅠb2 to Ⅱb cervical adenocarcinoma were randomly divided into the observation group(24 cases) and control group(20 cases).The control group were treated with radical surgery only,the observation group were treated with the whole uterus and double accessories resection combined with pelvic lymph node dissection after the chemotherapy of paclitaxel combined with cisplatin or nedaplatin for 1 to 2 courses.The tumor change in observation group was observed after chemotherapy.The lymphatic metastasis,intravascular cancer emboli,cervical infiltration,amount of bleeding,operation time and adverse reactions in two groups were compared.Results: The tumor shrank or disappeared after neoadjuvant chemotherapy,the clinical efficiency of which was 70.8%.The operation time of the observation group and control group were(180±30)min and(200±30)min,respectively,the amount of bleeding during operation of the observation group and control group were(400±50)ml and(450±50)ml,respectively.The operation time and amount of bleeding during operation in observation group were less than those in control group(P<0.05 and P<0.01).The occurrence rates of cervical deep stromal infiltration,intravascular cancer emboli and lymphatic metastasis in observation group and control group were 37.5% & 70.0%,25.0% & 55.5% and 12.5% & 40.0%,respectively,these data in observation group were lower than those in control group(P<0.05).The resection rates of vaginal margin in observation group and control group were 0.0% and 15.0 %,respectively,the difference of which was not statistically significant(P>0.05).Conclusions: Neoadjuvant chemotherapy can improve the clinical effects of surgery on stageⅠb2 to Ⅱb cervical adenocarcinoma.