Correlation between HBV-DNA and routine serum markers in patients with hepatitis B virus infection

Objective: To explore the correlation between hepatitis B virus(HBV)-DNA load and routine serum markers in patients with HBV infection.Methods: The serum HBV-DNA,hepatitis B virus surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg) and alanine aminotransferase(ALT) in 214 patients with HBV infection were detected using TaqMan real time polymerase chain reaction,chemiluminescence and rate assay.The relationship between the markers were analyzed.Results: Among the 214 patients,the positive rates of HBV-DNA and HBeAg were 57.48% and 28.04%,respectively.The HBV-DNA load was not related to HBsAg and ALT(P>0.05),and was closely related to the HBeAg level(P<0.01).The levels of HBeAg and ALT in positive HBV-DNA group were significantly higher than those in negative HBV-DNA group(P<0.01).Conclusions: The HBV-DNA load is positive correlation with the HBeAg level,and is not correlation with HBsAg and ALT.The HBsAg level standing for HBsAg still nends be further validated