Macrophage apoptosis induced by short-chain fatty acid stressed Salmonella typhi

Objective: To compare the difference of the apoptosis of macrophage induced by Salmonella typhi(S.typhi) and that treated by short-chain fatty acid(SCFA).Methods: The apoptosis ratio of macrophage at different times after infection with S.typhi or its SCFA forms were determined by flow cytometry.Results: Both S.typhi and its SCFA forms induced apoptosis of the macrophage with significant difference in the rates of apoptosis compared with those of the control(P<0.01).However,the rate of apoptosis induced by SCFA forms was obviously higher than that by S.typhi(P<0.01).Conclusions: SCFA may promote the apoptosis of macrophage.