The expression and significance of interleukin-6 in epithelial ovarian carcinoma

Objective: To explore the expression and significance of interleukin-6 in epithelial ovarian carcinoma.Methods: Twenty epithelial ovarian carcinomas and ten normal ovarian tissues were examined by Western blot and RT-PCR in the protein and mRNA level.Results: The expression of IL-6 in epithelial ovarian carcinoma was obviously lower than that in normal ovarian tissue,both in protein and mRNA level,the difference had statistic significance(P=0.000).Conclusions: The low expression of interleukin-6 in epithelial ovarian carcinoma provides the experimental evidence for the further study on the the effect of interleukin-6 on the development of ovarian cancer.