Effects of sanchipowder on the tumor growth and immune function in sarcoma S180 transplanted mice

Objective: To observe the inhibitory effects of sanchi powder on the growth of tumor and the influence of immunologic function on sarcoma 180(S180 bearing mice,and to supply experimental data for the research of high efficiency and low toxicity antitumor drugs.Methods: The models of S180 ascitic tumor and solid tumor were established and divided respectively into sodium carboxymethycellulose(SCMC) group,cyclophosph-amide(CTX) group and sanchi powder of low(3 mg/kg),middle(6 mg/kg) and high(12 mg/kg) groups;then the life span and the life extension rate of the mice with ascitic tumor were observed.The weight of the tumor,spleen,and thymus was measured;the antitumor rate,indexes of spleen and thymus of the mice with solid tumor were caculated;the statistical analysis was made among the groups.Results: Compared with the SCMC group,the survival rates of the middle and high dose sanchi powder groups and CTX group increased(P<0.05-P<0.01) and the tumor weight decreased(P<0.05-P<0.01).Compared with the SCMC group and CTX group,the indexes of spleen and thymus of both the middle and high dose sanchi powder groups increased(P<0.05-P<0.01).Conclusions: Sanchi powder has inhibitory effects on the growth of transplanted tumor and may enhance the immunologic function of S180 bearing mice.