Expressions of Skp2 and Ki67 in cervical carcinoma and its clinical significance

Objective: To explore the expressions of Skp2 and Ki67 in cervical intraepithelial neoplasia and cervix carcinoma and its clinical significance.Methods: The expressions of Skp2 and Ki67 were assessed by immunohistochemistry (EliVision) in cervical specimens,including 60 cases of cervix carcinoma,30 cases of cervical intraepithelial neoplasia (CIN),and 30 cases of normal cervical epithelia.The expression changes of Skp2 and Ki67 proteins in the formation of cervical intraepithelial neoplasia and cervix carcinoma and the relationship between the clinical features and pathological features were analyzed.Results: The positive rates of Skp2 and Ki67 in normal cervical epithelia,CIN and cervix carcinoma were 13.3%,66.7%,71.7% and 16.7%,56.7%,83.3%,respectively;the positive rates of both in CIN and cervix carcinoma were notably higher than in normal cervical epithelia (P<0.01);and there had some relationship of Skp2 and Ki67 in the same cervical carcinoma tissues (P<0.05).Conclusions: Skp2 and Ki67 expressions may play an important role in the development and progression of cervical carcinoma;Skp2 and Ki67 could be used as markers for early diagnosis of cervix carcinoma.It can be helpful for increasing the ratio of early diagnosis of cervix carcinoma.