Amplatz thrombectomy device combined with arteriovenous fistula treating deep venous thrombosis in dogs

Objective: To compare the effects of Amplatz thrombectomy device(ATD),arteriovenous fistula(AVF),ATD+AVF and no-operation(C)in treatment of deep venous thrombosis in dogs.Methods: The right femoral veins of 29 adult mongrel dogs were ligated proximally and were clamped distally by hemostatic forceps.After 48 hours,the thrombosis model was established.The thrombosed veins were treated with ATD(n=8),AVF(n=8),and ATD+AVF(n=8),C(n=5),respectively.Results: In each group,the expression of thrombomodulin(TM)gradually increased,but the climax in ATD+AVF group was less than other groups on 7th day.The expression of TM decreased to be normal at the time of 4th week(P>0.05).The transmission electron microscopy results showed that the endothelium injury degree of ATD+AVF group were mostly Ⅰ,Ⅱ grade(ATD+AVF vs AVF,C,P<0.005).Conclusions: The restored blood stream dynamics in time and temporary AVF are important to decrease the injury and maintain the potency of thrombosed veins.