Heart-type fatty acid binding protein in early diagnosis of acute myocardial infarction

Objective:To assess the value of heart-type fatty acid binding protein (H-FABP) in early diagnosis of acute myocardial infarction (AMI).Methods:Sixty cases of AMI patients were divided into 2 groups according to the time of receiving treatment.The H-FABP,cTnI and CK-MB were detected 0-3 hours and 4-6 hours after the onset.The sensitivity,specificity,positive predictive value and negative predictive value were calculated,and the results were analyzed and compared with those of the normal control and the angor pectoris group.Results:The level of plasma H-FABP concentration in the AMI patients receiving treatment 0-3 hours and 4-6 hours after onset was significantly higher than that of the the control group and the angor pectoris group (P<0.01);the sensitivity of H-FABP within 0-3 hours and 4-6 hours of onset was 67.74% and 89.66%,respectively in diagnosis of AMI,which was significantly higher than that of cTnI (29.03%,62.07%) and CK-MB (0.00%,58.62%) (P<0.01 and P<0.05);the positive predictive value and negative predictive value of H-FABP were 91.30% and 86.84%,CK-MB within 0-3 hours of onset were 0.00% and 68.69%.The specificity value of H-FABP within 0-3 hours and 4-6 hours of onset was 97.06%,which was similar to that of cTnI and CK-MB in diagnosis of AMI were 98.53% and 100.00%.Conclusions:H-FABP is superior to cTnI and CK-MB in diagnosis of AMI.