Clinical significance of determination of serum cardiac troponin I in patients with congestive heart failure

Objective: To determine the serum cardiac troponin I(cTnI) levels of patients with chronic congestive heart failure(CHF) and to investigate its relationship with cardiac function,left ventricular ejection fraction(LVEF) and serum creatinine(Cr).Methods: The serum cTnI and serum Cr concentration of 118 cases of CHF and 20 controls were detected.According to the cTnI level,the patients with CHF were divided into two groups.Results: The serum cTnI level of patients with CHF was significantly higher than that of the controls(P<0.05).Similar findings were observed in all the patients with CHF between cardiac function Ⅱ,Ⅲ and Ⅳ(P<0.01).The Cr level of patients with CHF was higher than that of the controls(P<0.001);And Cr concentration in the group of cTnI-positive was increased compared with that of cTnI-negative(P<0.001).No correlation was found between cTnI concentration and Cr level in the group of CHF(P>0.05).Conclusions: Serum cTnI concentration is closely related with CHF,which can act as an assisted predictor for the prognostic evaluation of CHF.